This gentleman has played the "Bioshock" demo (which I haven't had time to play), and came away confused as to whether the game's developer, Irrational Games, is for or against Ayn Rand's philosophy of Objectivism. From everything I've read, I'm uncertain myself.
Even the company's name says nothing, because an Objectivist might come up with such a name just for some irony. I suppose we'll have to wait until the game is released, but I fear that even then we might not know. Not unless the developer tells us, of course.